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COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE

The aim of this study was to propose an alternative statistic treatment for the results obtained by testing the in vitro efficacy of ivermectin (IVM) against R. microplus using the larval immersion test in order to detect the emergence of resistant strains. The statistical analysis of the results ob...

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Autor Principal: Torrents, J
Formato: Artículo revista
Publicado: Universidad Nacional del Litoral 2021
Acceso en línea:https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10954
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spelling oai:bibliotecavirtual.unl.edu.ar:article-109542021-12-07T17:01:29Z COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE COMPARACIÓN ENTRE EL MODELO PROBIT Y EL MODELO DE HILL PARA DETERMINAR LA EFICACIA DE IVERMECTINA SOBRE LARVAS DE Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) MEDIANTE LA TÉCNICA DE INMERSIÓN. Torrents, J The aim of this study was to propose an alternative statistic treatment for the results obtained by testing the in vitro efficacy of ivermectin (IVM) against R. microplus using the larval immersion test in order to detect the emergence of resistant strains. The statistical analysis of the results obtained by this technique is standardized by the FAO who proposes the use of the Probit model. However there are alternative mathematical models that allow a more precise analysis of experimental data generating more information as nonlinear logistic equation, also called the Hill model. The results of the IVM efficacy against a sensible strain of R. microplus were analysed whit both model. A comparison between the results obtained with PROBIT and Hill model showed that the last one was able to make a more precise fit of the experimental data, generating more information about small IVM concentrations.  The C50 (13.58 ppm) obtained with Probit model result smaller than the obtained with the Hill model (14.24 ppm), however the C90, C99 and the discriminant dose (19.31 ppm, 25.74 ppm, 51.48 ppm) obtained with de Hill model were bigger than the obtained with the Probit model (17.50 ppm, 21.98 ppm, 43.96 ppm). Universidad Nacional del Litoral 2021-12-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion artículo Articulo info:ar-repo/semantics/artículo https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10954 10.14409/favecv.v19isuplemento.10954 FAVE Sección Ciencias Veterinarias; Vol. 19 Núm. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; Vol 19 No suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; v. 19 n. suplemento (2021): FAVE Sección Ciencias Veterinarias 2362-5589 1666-938X 10.14409/favecv.v19isuplemento info:eu-repo/grantAgreement/EC/FP7/ info:eu-repo/semantics/openAccess Derechos de autor 2021 J Torrents http://creativecommons.org/licenses/by-nc-sa/4.0
institution Universidad Nacional del Litoral
collection Publicaciones periódicas
format Artículo revista
description The aim of this study was to propose an alternative statistic treatment for the results obtained by testing the in vitro efficacy of ivermectin (IVM) against R. microplus using the larval immersion test in order to detect the emergence of resistant strains. The statistical analysis of the results obtained by this technique is standardized by the FAO who proposes the use of the Probit model. However there are alternative mathematical models that allow a more precise analysis of experimental data generating more information as nonlinear logistic equation, also called the Hill model. The results of the IVM efficacy against a sensible strain of R. microplus were analysed whit both model. A comparison between the results obtained with PROBIT and Hill model showed that the last one was able to make a more precise fit of the experimental data, generating more information about small IVM concentrations.  The C50 (13.58 ppm) obtained with Probit model result smaller than the obtained with the Hill model (14.24 ppm), however the C90, C99 and the discriminant dose (19.31 ppm, 25.74 ppm, 51.48 ppm) obtained with de Hill model were bigger than the obtained with the Probit model (17.50 ppm, 21.98 ppm, 43.96 ppm).
author Torrents, J
spellingShingle Torrents, J
COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
author_facet Torrents, J
author_sort Torrents, J
title COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
title_short COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
title_full COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
title_fullStr COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
title_full_unstemmed COMPARISON BETWEEN THE PROBIT MODEL AND THE HILL MODEL TO DETERMINE THE EFFICACY OF IVERMECTIN ON Rhipicephalus (Boophilus) microplus (ACARI, IXODIDA: IXODIDAE) WITH LARVAL IMMERSION TECHNIQUE
title_sort comparison between the probit model and the hill model to determine the efficacy of ivermectin on rhipicephalus (boophilus) microplus (acari, ixodida: ixodidae) with larval immersion technique
publisher Universidad Nacional del Litoral
publishDate 2021
url https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10954
_version_ 1718763527939817472
score 11.8626

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