ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS.
A dose of marbofloxacin (MFX) to treat gastrointestinal infections caused by E. coli in 3-week-old goats was estimated. The pharmacodynamics of MFX against E. coli was evaluated in vitro by estimation of minimum inhibitory concentration (MIC), minimum bactericide concentration (MBC) and mutant preve...
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Universidad Nacional del Litoral
2021
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| Acceso en línea: | https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10953 |
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oai:bibliotecavirtual.unl.edu.ar:article-109532021-12-07T16:54:52Z ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. ESTIMACIÓN DE UNA DOSIS DE MARBOFLOXACINA PARA CABRAS DE TRES SEMANAS DE EDAD MEDIANTE ANÁLISIS POBLACIONAL Dell’Elce, A A dose of marbofloxacin (MFX) to treat gastrointestinal infections caused by E. coli in 3-week-old goats was estimated. The pharmacodynamics of MFX against E. coli was evaluated in vitro by estimation of minimum inhibitory concentration (MIC), minimum bactericide concentration (MBC) and mutant prevention concentration (MPC). Marbofloxacin was administered to six 3-week-old goats by subcutaneous route at the dose of 2 mg/kg. The pharmacokinetic parameters were estimated by non-compartmental analysis. The dose of MFX capable to protect the 95% of population was calculated considering the population distribution of pharmacokinetic parameters. The efficacy of MFX was evaluated by the relationship between the area under curve and MPC (AUC/MPC) with a cut-off value of 22 h. The results showed that the estimated dose of MFX to reach the clinical outcome of gastrointestinal infections caused by E. coli and to prevent the bacterial resistance at the 95% of the population of 3-week-old goats was 3,179 mg/kg, which for practical reasons was fixed at 3,5 mg/kg. The in vivo efficacy of dose estimated will be tested in future studies. Universidad Nacional del Litoral 2021-12-07 info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion artículo Articulo info:ar-repo/semantics/artículo https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10953 10.14409/favecv.v19isuplemento.10953 FAVE Sección Ciencias Veterinarias; Vol. 19 Núm. suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; Vol 19 No suplemento (2021): FAVE Sección Ciencias Veterinarias FAVE Sección Ciencias Veterinarias; v. 19 n. suplemento (2021): FAVE Sección Ciencias Veterinarias 2362-5589 1666-938X 10.14409/favecv.v19isuplemento info:eu-repo/grantAgreement/EC/FP7/ info:eu-repo/semantics/openAccess Derechos de autor 2021 A Dell’Elce http://creativecommons.org/licenses/by-nc-sa/4.0 |
| institution |
Universidad Nacional del Litoral |
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Publicaciones periódicas |
| format |
Artículo revista |
| description |
A dose of marbofloxacin (MFX) to treat gastrointestinal infections caused by E. coli in 3-week-old goats was estimated. The pharmacodynamics of MFX against E. coli was evaluated in vitro by estimation of minimum inhibitory concentration (MIC), minimum bactericide concentration (MBC) and mutant prevention concentration (MPC). Marbofloxacin was administered to six 3-week-old goats by subcutaneous route at the dose of 2 mg/kg. The pharmacokinetic parameters were estimated by non-compartmental analysis. The dose of MFX capable to protect the 95% of population was calculated considering the population distribution of pharmacokinetic parameters. The efficacy of MFX was evaluated by the relationship between the area under curve and MPC (AUC/MPC) with a cut-off value of 22 h. The results showed that the estimated dose of MFX to reach the clinical outcome of gastrointestinal infections caused by E. coli and to prevent the bacterial resistance at the 95% of the population of 3-week-old goats was 3,179 mg/kg, which for practical reasons was fixed at 3,5 mg/kg. The in vivo efficacy of dose estimated will be tested in future studies. |
| author |
Dell’Elce, A |
| spellingShingle |
Dell’Elce, A ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| author_facet |
Dell’Elce, A |
| author_sort |
Dell’Elce, A |
| title |
ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| title_short |
ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| title_full |
ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| title_fullStr |
ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| title_full_unstemmed |
ESTIMATION OF A DOSE OF MARBOFLOXACIN FOR 3-WEEK-OLD GOATS BY POPULATION ANALYSIS. |
| title_sort |
estimation of a dose of marbofloxacin for 3-week-old goats by population analysis. |
| publisher |
Universidad Nacional del Litoral |
| publishDate |
2021 |
| url |
https://bibliotecavirtual.unl.edu.ar/publicaciones/index.php/FAVEveterinaria/article/view/10953 |
| _version_ |
1718763527473201152 |
| score |
11.8626 |